Genome‐wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis
J Delgado‐Calle, AF Fernández, J Sainz… - Arthritis & …, 2013 - Wiley Online Library
Objective To determine genome‐wide methylation profiles of bone from patients with hip
osteoarthritis (OA) and those with osteoporotic (OP) hip fractures. Methods Trabecular bone
pieces were obtained from the central part of the femoral head of 27 patients with hip
fractures and 26 patients with hip OA. DNA was isolated, and methylation was explored with
Illumina methylation arrays. RNA was extracted, pooled, and deep‐sequenced to obtain the
whole transcriptome. Differentially methylated regions were identified, and connections …
osteoarthritis (OA) and those with osteoporotic (OP) hip fractures. Methods Trabecular bone
pieces were obtained from the central part of the femoral head of 27 patients with hip
fractures and 26 patients with hip OA. DNA was isolated, and methylation was explored with
Illumina methylation arrays. RNA was extracted, pooled, and deep‐sequenced to obtain the
whole transcriptome. Differentially methylated regions were identified, and connections …
Genome-wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis
J Sainz, JA Riancho - 2013 - digital.csic.es
[Objective]: To determine genome-wide methylation profiles of bone from patients with hip
osteoarthritis (OA) and those with osteoporotic (OP) hip fractures.[Methods]: Trabecular bone
pieces were obtained from the central part of the femoral head of 27 patients with hip
fractures and 26 patients with hip OA. DNA was isolated, and methylation was explored with
Illumina methylation arrays. RNA was extracted, pooled, and deep-sequenced to obtain the
whole transcriptome. Differentially methylated regions were identified, and connections …
osteoarthritis (OA) and those with osteoporotic (OP) hip fractures.[Methods]: Trabecular bone
pieces were obtained from the central part of the femoral head of 27 patients with hip
fractures and 26 patients with hip OA. DNA was isolated, and methylation was explored with
Illumina methylation arrays. RNA was extracted, pooled, and deep-sequenced to obtain the
whole transcriptome. Differentially methylated regions were identified, and connections …
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